Non-Injurious Neonatal Hypoxia Confers Resistance to Brain Senescence in Aged Male Rats
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Non-Injurious Neonatal Hypoxia Confers Resistance to Brain Senescence in Aged Male Rats
Whereas brief acute or intermittent episodes of hypoxia have been shown to exert a protective role in the central nervous system and to stimulate neurogenesis, other studies suggest that early hypoxia may constitute a risk factor that influences the future development of mental disorders. We therefore investigated the effects of a neonatal "conditioning-like" hypoxia (100% N₂, 5 min) on the bra...
متن کاملAltered astrocyte-neuronal interactions after hypoxia-ischemia in the neonatal brain in female and male rats.
BACKGROUND AND PURPOSE Increased susceptibility to excitotoxicity of the neonatal brain after hypoxia-ischemia (HI) may be caused by limited capacity of astrocytes for glutamate uptake, and mitochondrial failure probably plays a key role in the delayed injury cascade. Male infants have poorer outcome than females after HI, possibly linked to differential intermediary metabolism. METHODS [1-(1...
متن کاملBrain metabolic changes in young vs aged rats during hypoxia.
Brain energy state and glycolytic metabolites were measured in young (6 month) and aged (28 month) male rats under normoxic (70% nitrous oxide, 30% oxygen) or hypoxic (PaO2 = 25 mm Hg) test conditions. Hypoxic ischemia was induced in one cerebral hemisphere by ligation of one carotid artery. Under normoxic test conditions brain energy metabolite concentrations were similar between young and age...
متن کاملBrain Metabolic Changes in Young vs Aged Rats During Hypoxia
and neuropathology of cerebral "anoxic-ischemic" cell change. Arch Neurol 29: 367-374, 1973 20. Rice JE, Vannucci RC, Brierley JB: The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9: 131-141, 1981 21. Salford LG, Plum F, Siesjo BK: Graded hypoxia-oligemia in rat brain. Arch Neurol 29: 227-233, 1973 22. Levine S: Anoxic ischemic encephalopathy in rats. Am J Pat...
متن کاملCerebrovascular response to hypoxia in young vs aged rats.
Cerebrovascular responses of young and aged rats were tested to graded levels of hypoxia using a modification of the Levine ischemic-hypoxic rat model in which one carotid artery was ligated. Rats were anesthetized with 70% N2O, 30% O2 and cortical and subcortical cerebral blood flow (CBF) were measured with radioactive microspheres. CBF and cerebral cortical oxygen consumption (CMRO2) were mea...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0048828